• B-Fabp4-iCre mice

    C57BL/6N-Fabp4tm1(icre)Bcgen/Bcgen • 110152

    B-Fabp4-iCre mice

    Catalog Number: 110152
    Strain Name: C57BL/6N-Fabp4tm1(icre)Bcgen/Bcgen
    Strain Background: C57BL/6N
    NCBI gene ID: 11770 (Mouse)
    Aliases: Ap2; P15; ALBP; Lbpl; AFABP; 422/aP2; ALBP/Ap2
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    B-Fabp4-iCre mice

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    • Description
    • Targeting strategy
    • Phenotypic analysis

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      发表文章

        Description

        Homozygous knockout mice are viable and fertile. Compared to wild-type mice, FABP4-deficient mice exhibit increased susceptibility to diet-induced obesity.

        Gene editing strategy
        Phenotype Analysis
        Scheme for generating RhebADKO mice.The RhebFL/FLmice were crossed with Fabp4-Cremice (Fabp4-Cre micewere purchased from Biocytogen Co.Ltd., Beijing, China) to obtain RhebADKO mice. Rheb was not detected in the interscapular BAT, inguinal and epididymal WAT of RhebADKO mice. Compared to control mice, the interscapular BAT pads of RhebADKO mice were significantly lighter and smaller, while no significant differences were observed in the inguinal and epididymal WAT.
        Instructions of genomic DNA extraction

        chematic representation of the toe clipping.

        * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-Fabp4-iCre mice] (Cat# 110152) was purchased from Biocytogen.
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